Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling
J. Clin. Invest. Sophie Lanone, et al. 110:463 doi:10.1172/JCI14136 [
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Figure 2Effects of MMP deficiency on IL-13–induced alterations in lung volume and alveolar size. CC10-rtTA-IL-13 transgene
– and transgene
+ mice with wild-type and null MMP-9 or MMP-12 loci were generated and placed on dox water at 1 month of age. They were maintained on this regimen for an additional month, at which time their lungs were removed and fixed to pressure. Lung volume (
a and
c) and alveolar size (chord length;
b and
d) were assessed as described in Methods. The noted values represent the mean ± SEM of a minimum of five animals in each group (*
P < 0.01).
