Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease
J. Clin. Invest. Xiaoying Hou, et al. 109:533 doi:10.1172/JCI14099 [
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Figure 1Integrated genetic and physical map of the
cpk candidate interval. Recombination analyses refined the
cpk locus to an approximately 100-kb interval, centered on
D12Mit12 and delimited by
221A10SP6 and
Rrm2 (indicated in b is;
a). These data positioned
cpk on a single BAC,
221A10, within our yeast and bacterial artificial cromosome (YAC/BAC)-based physical map (
b). Computational analyses identified six putative transcriptional units within the
cpk interval, and each predicted gene corresponded, at least in part, to a mouse UniGene cluster (
c).
