Lior Carmon, Irene Bobilev-Priel, Baruch Brenner, Dimitry Bobilev, Adrian Paz, Erez Bar-Haim, Boaz Tirosh, Tirza Klein, Mati Fridkin, Francois Lemonnier, Esther Tzehoval, Lea Eisenbach
J Clin Invest.
2002;
110(4):453–462
doi:10.1172/JCI14071
This article Copyright © 2002, The American Society for Clinical Investigation
Abstract
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T
he human milk fat globule membrane protein BA46 (lactadherin) is highly overexpressed in human breast tumors, making it a potential target for tumor immunotherapy. We have identified BA46-derived peptides that contain the motif recognized by the MHC class I molecule HLA-A2.1 and that are processed and presented by human breast carcinoma cells. In mice lacking normal class I molecules but expressing an HLA-A2.1/Db-β2 microglobulin single chain (HHD mice), three peptides elicited specific CTL activity. Two of these peptides also stimulated cytotoxic activity in peripheral blood lymphocytes from HLA-A2.1–positive breast carcinoma patients. Adoptive transfer of HHD-derived bulk CTLs to nude mice bearing human breast carcinoma transplants reduced tumor growth. These peptides therefore represent naturally processed BA46-derived CTL epitopes that can be used in peptide-based antitumor vaccines.
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