Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice
J. Clin. Invest. Jeffrey B. Hodgin, et al. 109:541 doi:10.1172/JCI14066 [Go to this article.]

Figure 2
BP in gonadectomized NNee and nnee mice treated with a control pellet (Gdx) or an E2-containing pellet. Lower number in each bar is sample size (n). Upper number in each bar is mean BP, with SEM represented as a vertical line. The BP measurements for male (10 NNee and 14 nnee Gdx, and 10 NNee and 9 nnee E2) and female (12 NNee and 15 nnee Gdx; 10 NNee and 9 nnee E2) mice were combined as described in Methods. In NNee and nnee mice, exogenous E2 treatment results in a significant decrease in BP. *P < 0.05 versus Gdx mice of the same genotype (Student t test with Bonferroni correction for multiple comparisons).