Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice
J. Clin. Invest. Jeffrey B. Hodgin, et al. 109:541 doi:10.1172/JCI14066 [
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Figure 1BP and atherosclerotic lesion size in
NNee and
nnee mice, either gonadectomized and implanted with a control pellet (Gdx) or surgically intact (I). I
1, current data; I
2, cumulative data. The lower number in each bar is sample size (
n). The upper number in each bar is mean BP (mmHg) or lesion size (×10
3 μm
2), with SEM represented as a vertical line. (
a) The BP measurements for male mice (10 Gdx
NNee and 14 Gdx
nnee; 35 I
2 NNee and 19 I
2 nnee) and female mice (12 Gdx
NNee and 15 Gdx
nnee; 22 I
2 NNee and 18 I
2 nnee; see Results for number of I
1 male and female mice) were combined as described in Methods. Removal of endogenous sex hormones by gonadectomy results in a significant reduction in BP in
nnee mice (*
P < 0.05 versus I
2, Student’s
t test with Bonferroni correction for multiple comparisons). (
b) Removal of endogenous sex hormones by gonadectomy results in a significant decrease in atherosclerotic lesion size in
nnee mice (*
P < 0.05 versus I
2, Student
t test with Bonferroni correction for multiple comparisons).
