JCI - Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO4 receptor is critical for implantation in vivo

Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO₄ receptor is critical for implantation in vivo

Yiling Mi, Steven D. Shapiro, Jacques U. Baenziger

Published in Volume 109, Issue 2

J Clin Invest. 2002; 109(2):269–276 doi:10.1172/JCI13997

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Figure 2

Female mice heterozygous for deletion of the Man/GalNAc-4-SO₄ receptor have smaller numbers of pups per litter. M/G4S-R^+/+ and M/G4S-R^+/– female mice were bred with both M/G4S-R^+/+ and M/G4S-R^+/– male mice. The number of pups born was determined the morning of delivery. There was no apparent difference in appearance or survival rate following delivery. Bars indicate the median value for each group. Mean values of 4.7 (n = 63) for female M/G4S-R^+/– × male M/G4S-R^+/–, 5.2 (n = 25) for female M/G4S-R^+/– × male M/G4S-R^+/+, 9.0 (n = 11) for female M/G4S-R^+/+ × male M/G4S-R^+/–, and 9.8 (n = 20) for female M/G4S-R^+/+ × male M/G4S-R^+/+ pups per litter were obtained. ANOVA analysis using Tukey’s multiple comparison test indicated that differences between the means of female M/G4S-R^+/– × male M/G4S-R^+/– and female M/G4S-R^+/– × male M/G4S-R^+/+, or between female M/G4S-R^+/+ × male M/G4S-R^+/– and female M/G4S-R^+/+ × male M/G4S-R^+/+, were not significant (P > 0.05). Differences between the means for either female M/G4S-R^+/– × male M/G4S-R^+/– or female M/G4S-R^+/– × male M/G4S-R^+/+, and either female M/G4S-R^+/+ × male M/G4S-R^+/– or female M/G4S-R^+/+ × male M/G4S-R^+/+, were highly significant (P < 0.001).