CD4⁺ T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis
J. Clin. Invest. Jean Wu, et al. 109:517 doi:10.1172/JCI13876 [Go to this article.]

Figure 5
Development of GN in the rCol4α3NC1-specific T cell recipients. (a) Histology shows a glomerulus with fibrin deposition and crescent formation. Adjacent to the glomerulus is a mononuclear infiltrate. Focal tubules are dilated and contain intensely eosinophilic material consistent with protein. (b) Immunoperoxidase staining shows CD3⁺ T cells (brown in color) in mononuclear cell infiltrate surrounding a glomerulus with crescentic lesion. (c) Immunofluorescence stain show CD11b/c⁺ monocytes/macrophages (red) clustered in the Bowman’s space of an affected glomerulus. GBM and TBM are counterstained green by FITC-labeled SR-6. Arrowheads outline the basement membrane of the Bowman’s capsule.