CD4⁺ T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis
J. Clin. Invest. Jean Wu, et al. 109:517 doi:10.1172/JCI13876 [Go to this article.]

Figure 1
Antigen specificities of a T cell line generated from rCol4α3NC1-immunized rat. (a) An rCol4α3NC1 T cell line (filled circles) or T cells from CFA-immunized rat (open circles) were incubated with different concentrations of rCol4α3NC1 (x axis) in the presence of irradiated syngeneic thymocytes. The proliferation of T cells was measured as uptake of ³H (Δcpm, y axis). (b) T cells’ responses to digested rat GBM.