Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology
J. Clin. Invest. Ulla-Angela Temann, et al. 109:29 doi:10.1172/JCI13696 [Go to this article.]

Figure 4
Lung histology of conducting airways and parenchyma. Lung sections from IL-9 transgene-negative (a) and -positive (b–d) mice were stained with H&E for examination using light microscopy. Induction of the IL-9 transgene by doxycycline over a period of 7 days (c) or 14 days (d) resulted in infiltration of lung tissue with inflammatory cells. Furthermore, airway epithelial cells were hypertrophic (arrows). Inflammatory cells were not observed in lung sections from six-week-old transgene-negative (a) or -positive (b) mice without doxycycline treatment. Original magnification ×300.