Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology
J. Clin. Invest. Ulla-Angela Temann, et al. 109:29 doi:10.1172/JCI13696 [Go to this article.]

Figure 1
Genetic constructs used for the generation of transgenic mice with regulated overexpression of IL-9 by doxycycline. The inducible, lung-specific expression system consists of two separate constructs. (a) The first construct contains the rtTA cDNA under the control of the lung epithelial cell–specific, rat CC10 promoter and the hGH intronic and polyadenylation sequences. (b) In the second construct the IL-9 cDNA is linked to the tet-O-CMV promoter and the SV 40 small t intron and polyadenylation sequence.