Suppression of body fat accumulation in myostatin-deficient mice
J. Clin. Invest. Alexandra C. McPherron, et al. 109:595 doi:10.1172/JCI13562 [Go to this article.]

Figure 4
Mstn deletion partially suppresses fat accumulation and delays hyperglycemia in Lep^ob/ob mice. (a and b) Decrease in fat pad weights in male (a) (n = 5–8) and female (b) (n = 5–6) Lep^ob/ob, Mstn^–/– 8-week-old mice. Orange bars designate the mean, and symbols designate individual animals. Black, Lep^ob/ob, Mstn^+/+; pink, Lep^ob/ob, Mstn^–/–. Diamonds, males; circles, females. (c and d) Suppression of abnormal fed glucose levels in Lep^ob/ob, Mstn^–/– male (c) (n = 6–22) and female (d) (n = 8–26) mice. Symbols are as in a and b. *P < 0.05, **P < 0.01, ***P < 0.001, Student’s t test.