Suppression of body fat accumulation in myostatin-deficient mice
J. Clin. Invest. Alexandra C. McPherron, et al. 109:595 doi:10.1172/JCI13562 [Go to this article.]

Figure 3
Mstn deletion partially suppresses fat accumulation and glucose intolerance in A^y mice. (a) Effect of Mstn deletion on appearance of a/a and A^y/a female mice. (b and c) Effects of Mstn deletion on fat pad weights in 7-month-old A^y male (b) (n = 6–9) and female (c) (n = 8–20) mice. Orange bars designate the mean, and symbols designate individual animals. Black, A^y/a, Mstn^+/+; pink, A^y/a, Mstn^–/–. Diamonds, males; circles, females. (d and e) Suppression of abnormality of glucose tolerance tests in male (d) (n = 4) and female (e) (n = 5–13) Mstn^–/– mice. Symbols are as in b and c. Some measurements exceeded the upper detection limit of the glucose test (600 mg/dl). *P < 0.05, ***P < 0.001, Student’s t test.