Suppression of body fat accumulation in myostatin-deficient mice
J. Clin. Invest. Alexandra C. McPherron, et al. 109:595 doi:10.1172/JCI13562 [Go to this article.]

Figure 1
Mstn deletion suppresses fat accumulation. (a) Increased mass of triceps muscle in Mstn^–/– mice at different ages (n = 4–13). Black, Mstn^+/+; blue, Mstn^+/–; pink, Mstn^–/–. Data are expressed as mean ± SEM. (b–f) Mass of male epididymal (b), retroperitoneal (c), and inguinal (d), and female parametrial (e) and retroperitoneal (f) fat pads at different ages (n = 4–13). Orange bars designate the mean, and symbols designate individual animals colored as in a, with diamonds for males and circles for females. ^#P = 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, Student’s t test. (g) Serum concentration of leptin to mass of total body fat in individual 8-month-old male mice. (h) Fat cell histology in epididymal fat pads. Scale bar = 50 μm.