Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle
J. Clin. Invest. Ana M. Fernández, et al. 109:347 doi:10.1172/JCI13503 [Go to this article.]

Figure 4
Comparison of ERK1/2, p44/42, p38, JNK, and Akt levels in WT versus MKR mice. Hindlimb muscles were removed from WT and MKR mice at the ages of 0–3 weeks, 5 weeks, and 8 weeks, and subjected to Western blot analysis. (a) Representative blots showing phospho-p44/42 MAP kinase (upper panel), ERK1/2 (middle panel), and β-actin (lower panel) immunoreactivity levels in MKR and WT mice. (b) Representative blots showing phospho-p38 (upper panel), p38 (middle panel), and β-actin (lower panel) immunoreactivity levels in MKR and WT mice. (c) Representative blots showing phospho-JNK (upper panel) and JNK (lower panel) immunoreactivity levels in MKR and WT mice. (d) Representative blots showing phospho-Akt (upper panel) and Akt (lower panel) immunoreactivity levels in MKR and WT mice. Each blot represents three independent experiments, using five animals in each group.