Jci_page_head_homepage_01 Jci_page_head_homepage_02
Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways
Charles N. Serhan, Ernst Oliw
Published in Volume 107, Issue 12
J Clin Invest. 2001; 107(12):1481–1489 doi:10.1172/JCI13375
This article Copyright © 2001, The American Society for Clinical Investigation
Full text | PDF | Supplemental material
Options: View larger image (or click on image)
Medium
Figure 1

Cyclooxygenase reactions and products: prostaglandins and the impact of aspirin. Conversion of arachidonic acid to bioactive products involves stereoselective insertion of oxygen governed by COX (see text for details). Aspirin blocks formation of PGs from COX-1 and -2. In addition, with COX-2, aspirin triggers the formation of bioactive aspirin-triggered lipid mediators.

Copyright © 2011 American Society for Clinical Investigation.
The JCI is the publication of the ASCI, an honor society of physician-scientists.
Copying, redistribution, and other usage policies