Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes
J. Clin. Invest. N. Manjunath, et al. 108:871 doi:10.1172/JCI13296 [Go to this article.]

Figure 3
IL-15 reduces activation and cytotoxic function of fully differentiated effector CTLs. P14XT-GFP Tg splenocytes were stimulated with the gp33 peptide and cultured in 20 ng/ml IL-2 for 7 days. The cells were then washed and maintained in either IL-2 or IL-15 (20 ng/ml) for the next 5 days before testing for activation phenotype (a) and peptide-specific cytotoxicity (b). Overlay histograms of cells cultured in IL-2 (squares) and IL-15 (circles) are shown after gating for CD8 expression in a. Data for two sets of independent cell lines are shown in b.