A simplified overview of arachidonate esterification and phospholipid remodeling in cells. The key enzymes are (I) Acyl Coenzyme A synthetase (or ligase), (II) PC/CoA-AA, phosphatidylcholine/CoA arachidonate transacylase, (III) CoA-IT, CoA-independent transacylase, and (IV) iPLA₂, calcium-independent PLA₂. Not shown are distinct pools of free arachidonic acid that may be generated in subcellular compartments by the actions of other lipases (such as secreted PLA₂ [sPLA₂], cytosolic PLA₂ [cPLA₂], phospholipases C or D [PLC, PLD]), e.g. on the nuclear membrane for leukotriene biosynthesis. AA, arachidonic acid; TG, triglyceride.