Accelerated apoptosis in the Timp-3–deficient mammary gland
J. Clin. Invest. Jimmie E. Fata, et al. 108:831 doi:10.1172/JCI13171 [
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Figure 4Gelatin zymography of mammary protein extracts from 10L to 3di from wild-type and
Timp-3–null mammary glands. Activation of pro–MMP-2 (70-kDa and 68-kDa bands) to an active form (62 kDa) occurred at 3di in wild-type mammary tissue. In contrast, the activated species was evident during lactation and at 1di and 2di of involution in
Timp-3–deficient mammary glands (arrowheads). The upper band (∼105 kDa) in both zymograms likely represents pro–MMP-9 and did not show differential regulation.
