Accelerated apoptosis in the Timp-3–deficient mammary gland
J. Clin. Invest. Jimmie E. Fata, et al. 108:831 doi:10.1172/JCI13171 [Go to this article.]

Figure 1
Early loss of milk secretion and β-casein expression in Timp-3–null mammary glands during involution. (a) Upon initiation of involution, the mammary gland to body weight ratio increased in wild-type (WT) mice but not in Timp-3–null mice. Significant differences were found at 2di. *P < 0.05. No differences were found thereafter. All time points were derived from at least n = 2 mice per genotype and are shown as mean ± SEM. (b) β-Casein protein declined rapidly after 1di in Timp-3–null mice compared with its gradual loss in wild-type mice. Immunoblot is representative of two separate experiments. Equal loading was confirmed by staining the membrane with Amido Black.