Carmen Guerra, Paloma Navarro, Angela M. Valverde, Monica Arribas, Jens Brüning, Leslie P. Kozak, C. Ronald Kahn, Manuel Benito
J Clin Invest.
2001;
108(8):1205–1213
doi:10.1172/JCI13103
This article Copyright © 2001, The American Society for Clinical Investigation
Abstract
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lthough insulin regulates metabolism in both brown and white adipocytes, the role of these tissues in energy storage and utilization is quite different. Recombination technology using the Cre-loxP approach allows inactivation of the insulin receptor in a tissue-specific manner. Mice lacking insulin receptors in brown adipocytes show an age-dependent loss of interscapular brown fat but increased expression of uncoupling protein-1 and -2. In parallel, these mice develop an insulin-secretion defect resulting in a progressive glucose intolerance, without insulin resistance. This model provides direct evidence for not only a role for the insulin receptors in brown fat adipogenesis, the data also suggest a novel role of brown adipose tissue in the regulation of insulin secretion and glucose homeostasis.
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