Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development
J. Clin. Invest. Eric Meffre, et al. 108:879 doi:10.1172/JCI13051 [Go to this article.]

Figure 3
Igκ light chain repertoire in pro-B cells. (a) J_κ usage in 108 peripheral B, 22 control pro-B, 38 Igμ^–/–, and 37 Igμ^Δ pro-B V_κJ_κ individual sequences. Percentages of J_κ usage are indicated. (b) V_κ usage in upstream Jκ1 and Jκ2 (Jκ1-2; top) and downstream Jκ3, Jκ4, and Jκ5 (Jκ3-4-5; bottom) rearrangements of peripheral B cells (white bars), control pro-B (light gray bars), Igμ^–/– (black bars), and Igμ^Δ (darkgray bars) pro-B cells. The V_κ genes are subdivided in four groups on the locus (84). The percentages of each V_κ group are indicated on the y axis. *Statistically significant difference (P < 0.001).