Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development
J. Clin. Invest. Eric Meffre, et al. 108:879 doi:10.1172/JCI13051 [
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Figure 2IgH CDR3 characteristics in pro-B cells. (
a) V
HDJ
H CDR3 length in 350 peripheral B cell (white bars), 117 in-frame control pro-B (gray bars), and 197
Igμ–/– (black bars) individual sequences. CDR3 length in amino acids (aa) is indicated below. The average CDR3 length for peripheral B, control pro-B, and
Igμ–/– pro-B cells was 13.5, 16.5, and 16.0 amino acids, respectively. (
b)
D reading frame usage in IgH CDR3s from peripheral B, control, and
Igμ–/– pro-B cells. The three RF uses reported by Corbett et al. (
50) for some commonly used
D gene segments are represented. D3-3 and
D3-10 encode no intragenic stop codons whereas
D6-13,
D2-15,
D4-17, and
D3-22 sequences using RF1 display stop codons.
