Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival
J. Clin. Invest. David T. Denhardt, et al. 107:1055 doi:10.1172/JCI12980 [Go to this article.]

Figure 2
Pro- and anti-inflammatory actions of OPN in cell injury and infection. The left side of the diagram summarizes proinflammatory and anti-inflammatory events believed to be regulated by OPN. The right side summarizes known or predicted events in the OPN-null mouse. The center illustrates the wounding of the epithelium or endothelium, which is followed by macrophage-mediated containment of an infecting agent and, finally, repair of the injury. MMP-2, matrix metalloproteinase 2; M, macrophage. See text for further details.