Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis
J. Clin. Invest. Martin Kolb, et al. 107:1529 doi:10.1172/JCI12568 [Go to this article.]

Figure 4
Lung histology in the first week after injection of AdhIL-1β showed acute inflammatory reactions in the lungs, beginning in peribronchial areas after 2 days (a). By day 7, inflammatory infiltrates affected large parts of the lung (b). In some areas, the cellular infiltrates completely filled alveoli while alveolar structures remained intact. In other regions, they caused marked alveolar wall destruction (c). The inflammatory infiltrates consisted mainly of neutrophils and macrophages, reaching the airway lumen after passing bronchial mucosa (d). Hematoxylin and eosin staining; ×24 (a and b); ×160 (c and d).