Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis
J. Clin. Invest. Martin Kolb, et al. 107:1529 doi:10.1172/JCI12568 [Go to this article.]

Figure 1
Proinflammatory cytokines in BAL fluid. (a) Transgene human IL-1β was elevated 2 days after injection of AdhIL-1β, was maximally expressed after 7 days, and returned to baseline by day 14. Endogenous TNF-α (b) and IL-6 (c) were upregulated parallel to hIL-1β and returned to baseline concentration by day 14. In control animals treated with AdDL70, hIL-1β, TNF-α, and IL-6 were not different from PBS-treated rats. ^AP < 0.008 versus AdDL70 control; ^BP < 0.02 versus AdDL70 control.