JCI - c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
J. Clin. Invest. 108:1 doi:10.1172/JCI12466 [Go to this article.]

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Figure 4

Effect of MAP kinase inhibitors on c-jun and c-fos gene expression. Cultured FLS were stimulated with medium or 2 ng/ml of IL-1 for 15 minutes in the presence of SP600125 (20 μM), PD98059 (100 μM), or SB203580 (3 μM). The figure is representative of four FLS lines examined. The c-jun and c-fos mRNA levels were determined by Northern blot analysis. RNA loading is shown in the bottom row with GAPDH. JNK inhibition decreased c-jun expression, while ERK inhibition decreased c-fos expression.