JCI - α4-integrin-VCAM-1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

α4-integrin-VCAM-1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels
J. Clin. Invest. 108:4 doi:10.1172/JCI12440 [Go to this article.]

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Figure 6

Localization of T lymphoblasts within the spinal cord parenchyma in control animals. Six hours after infusion of T lymphoblasts, the Cell Tracker Orange–labeled T cell blasts (red fluorescence) could be localized outside the spinal cord microvasculature (green fluorescence) within the spinal cord parenchyma of control animals. Superimposed fluorescence is shown, which demonstrates one T cell blast attached within the venule (yellow fluorescence) and one T cell blast within the spinal cord parenchyma (red fluorescence). Bar, 10 μm.