Published in Volume
101, Issue 3 (February 1, 1998)
J Clin Invest. 1998;101(3):682–688.
doi:10.1172/JCI119882.
Copyright ©
1998, The American Society for
Clinical Investigation.
Research Article
Adenosine(5') oligophospho-(5') guanosines and guanosine(5') oligophospho-(5') guanosines in human platelets.
H Schlüter, I Grobeta, J Bachmann, R Kaufmann, M van der Giet, M Tepel, J R Nofer, G Assmann, M Karas, J Jankowski and W Zidek
Med. Klinik I, Univ.-Klinik Marienhospital, University of Bochum, Hölkeskampring 40, 44625 Herne, Germany.
Published February 1, 1998
We isolated and identified nucleoside(5') oligophospho-(5') nucleosides containing adenosine and guanosine (ApnG; n = 3-6) as well as diguanosine polyphosphates (GpnG; n = 3-6) in human platelets. For identification, UV spectrometry, matrix-assisted laser desorption/ionization, postsource decay matrix-assisted laser desorption/ionization mass spectrometry, and enzymatic cleavage experiments were used. The adenosine(5') oligophospho-(5') guanosines act as vasoconstrictors and growth factors. The diguanosine polyphosphates are potent modulators of growth in vascular smooth muscle cells, but do not affect vascular tone.
