W Sun, J W IJdo, S R Telford, E Hodzic, Y Zhang, S W Barthold, E Fikrig
J Clin Invest.
1997;
100(12):3014–3018
doi:10.1172/JCI119855
This article Copyright © 1997, The American Society for Clinical Investigation
Abstract
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T
he agent of human granulocytic ehrlichiosis (HGE) is a newly recognized tick-borne pathogen that resides within polymorphonuclear leukocytes. C3H/HeN mice can become infected with the agent of HGE (designated aoHGE) by syringe inoculation or tick-borne infection and develop transient neutropenia. They thereby partially mimic human disease and provide a model in which to study immunity to this microorganism. Mice vaccinated with lysates of purified aoHGE, or administered aoHGE antisera, were partially protected from both syringe- and tick-transmitted challenge with aoHGE. These data suggest that antibodies are sufficient to provide substantial, but not complete, immunity against aoHGE.
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