Jean-Francois Pittet, Mark J.D. Griffiths, Tom Geiser, Naftali Kaminski, Stephen L. Dalton, Xiaozhu Huang, Lou Anne S. Brown, Phillip J. Gotwals, Victor E. Koteliansky, Michael A. Matthay, Dean Sheppard
J Clin Invest.
2001;
107(12):1537–1544
doi:10.1172/JCI11963
This article Copyright © 2001, The American Society for Clinical Investigation
Abstract
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e have shown that the integrin αvβ6 activates latent TGF-β in the lungs and skin. We show here that mice lacking this integrin are completely protected from pulmonary edema in a model of bleomycin-induced acute lung injury (ALI). Pharmacologic inhibition of TGF-β also protected wild-type mice from pulmonary edema induced by bleomycin or Escherichia coli endotoxin. TGF-β directly increased alveolar epithelial permeability in vitro by a mechanism that involved depletion of intracellular glutathione. These data suggest that integrin-mediated local activation of TGF-β is critical to the development of pulmonary edema in ALI and that blocking TGF-β or its activation could be effective treatments for this currently untreatable disorder.
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