Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo
J. Clin. Invest. Wolfgang E. Gallwitz, et al. 110:1559 doi:10.1172/JCI11936 [Go to this article.]

Figure 5
(a) Effect of 6-thioguanine on the area of osteolytic lesions. Osteolytic-lesion area was assessed by Faxitron (model 43855A, Faxitron X-ray Corp.) and computerized image analysis of hindlimb radiographs. MDA-MB-231 tumor cells were inoculated on day 0. Treatment with 6-thioguanine (1.0 mg/kg/day subcutaneously) was begun on the following day. Vertical arrows indicate the days of treatment. Values represent means ± SEM (n = 5 per group). *P < 0.05. (b) Representative radiographs of hindlimbs from mice bearing MDA-MB-231 tumors 28 days after tumor inoculation with and without treatment with 6-thioguanine (Figure 6a). Arrows indicate osteolytic lesions.