Advertisement

Citations to this article

Abstract

To evaluate the role of tumor necrosis factor (TNF alpha) in bone loss resulting from estrogen deficiency, the effects of ovariectomy were explored in six-month-old transgenic mice expressing high blood levels of a soluble TNF receptor type I (sTNFR1)-FcIgG3 fusion protein, which neutralizes TNF alpha, and in their nontransgenic littermates used as controls. These transgenic mice were identical to control mice in bone mass (evaluated by bone mineral density and content) and strength. 12 weeks after ovariectomy, the decrease in bone mass and increase in osteocalcin (marker of bone turnover) found in control mice were not observed in transgenic mice, which were not different from sham-operated mice, transgenic or not. This observation suggests a critical role for TNF alpha in the pathogenesis of bone loss induced by estrogen deficiency, a common cause of morbidity in postmenopausal women.

Authors

P Ammann, R Rizzoli, J P Bonjour, S Bourrin, J M Meyer, P Vassalli, I Garcia

×

Total citations by year in Crossref

Year: 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 Total
Citations: 1 7 8 7 6 2 5 8 8 13 4 3 5 7 8 11 9 3 115
Citation information

Citations to this article in Crossref (115)

Title and authors Publication Year
The effect of calcium and vitamin D supplementation on osteoporotic rabbit bones studied by vibrational spectroscopy
A Lani, N Kourkoumelis, G Baliouskas, M Tzaphlidou
Journal of Biological Physics 2014
Influence of sex steroids on inflammation and bone metabolism
HJ Shiau, ME Aichelmann-Reidy, MA Reynolds
Periodontology 2000 2013
The limited effects of anti-tumor necrosis factor blockade on bone health in patients with rheumatoid arthritis under the use of glucocorticoid
T Okano, T Koike, M Tada, Y Sugioka, K Mamoto, S Wakitani, H Nakamura
Journal of Bone and Mineral Metabolism 2013
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
MT Drake, S Khosla
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 2013
Advances in Osteoimmunology: Pathophysiologic Concepts and Treatment Opportunities
M Rauner, W Sipos, S Thiele, P Pietschmann
International Archives of Allergy and Immunology 2013
Osteoporosis
LF Bonewald
Osteoporosis International 2013
Biologic therapies and systemic bone loss in Rheumatoid Arthritis
T Dimitroulas, SN Nikas, P Trontzas, GD Kitas
Autoimmunity Reviews 2013
Catechins and osteoporosis
UN Das
Nutrition 2013
Role of T cells in ovariectomy induced bone loss-revisited
R Pacifici
Journal of Bone and Mineral Research 2012
Targeting tumor necrosis factor alpha (TNF-α) in diabetic rats could approve avenues for an efficient strategy for diabetic therapy
KK Abdul-Aziz, MJ Tuorkey
Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2012
Lokale und systemische Knocheneffekte bei rheumatoider Arthritis
M Rauner, LC Hofbauer, M Aringer
Zeitschrift für Rheumatologie 2012
Sirt1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway
W Huang, W Shang, H Wang, W Wu, S Hou
Acta Pharmacologica Sinica 2012
Estrogen and the Skeleton
S Khosla, MJ Oursler, DG Monroe
Trends in endocrinology and metabolism: TEM 2012
Effects of Chrysanthemum indicum L. Extract on the Function of Osteoblastic MC3T3-E1 Cells under Oxidative Stress Induced by Hydrogen PeroxideJee
JH Yun, ES Hwang, GH Kim
Korean Journal of Food Science and Technology 2012
Infliximab improves bone metabolism and bone mineral density in rheumatoid arthritis and ankylosing spondylitis: a prospective 2-year study
G Dischereit, IH Tarner, U Müller-Ladner, U Lange
Clinical Rheumatology 2012
The effect of TNFα secreted from macrophages activated by titanium particles on osteogenic activity regulated by WNT/BMP signaling in osteoprogenitor cells
SS Lee, AR Sharma, BS Choi, JS Jung, JD Chang, S Park, EA Salvati, EP Purdue, DK Song, JS Nam
Biomaterials 2012
Anti-TNFα therapy and prevention of bone loss in rheumatoid arthritis
C Roux
IBMS BoneKEy 2011
Inflammaging: The driving force in osteoporosis?
P Lencel, D Magne
Medical Hypotheses 2011
Distinct impacts of syndesmophyte formation on male and female patients with ankylosing spondylitis : Inflammatory factors and bone metabolism markers in AS
WN HUANG, TK TSO, YC KUO, GJ TSAY
International Journal of Rheumatic Diseases 2011
Review article: the effects of antitumour necrosis factor-α on bone metabolism in inflammatory bowel disease
SG Veerappan, CA O’Morain, JS Daly, BM Ryan
Alimentary Pharmacology & Therapeutics 2011
IL-33 is expressed in human osteoblasts, but has no direct effect on bone remodeling
S Saidi, F Bouri, P Lencel, L Duplomb, M Baud’huin, S Delplace, D Leterme, F Miellot, D Heymann, P Hardouin, G Palmer, D Magne
Cytokine 2011
The effects of Labisia pumila var. alata on bone markers and bone calcium in a rat model of post-menopausal osteoporosis
AN Shuid, LL Ping, N Muhammad, N Mohamed, IN Soelaiman
Journal of Ethnopharmacology 2011
Osteoimmunology
BF Boyce, L Xing, EM Schwarz
Osteoimmunology 2011
Evaluation of osteogenic activity of periosteal-derived cells treated with inflammatory cytokines
BW Park, MJ Choi, YS Hah, HY Cho, DR Kim, UK Kim, HJ Kang, JR Kim, JH Byun
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2010
Systemic bone effects of biologic therapies in rheumatoid arthritis and ankylosing spondylitis
CB Confavreux, RD Chapurlat
Osteoporosis International 2010

Advertisement
Advertisement