T J Liang, A E Reid, R Xavier, R D Cardiff, T C Wang
J Clin Invest.
1996;
97(12):2872–2877
doi:10.1172/JCI118744
This article Copyright © 1996, The American Society for Clinical Investigation
Abstract
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eceptor tyrosine kinases are important in cell signal transduction and proliferation. Abnormal expression of tyrosine kinases often leads to malignant transformation. C-met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor (HGF). HGF/c-met plays diverse role in regulation of cell growth, shape and movement. Constitutively activated met, such as tpr-met, is a potent oncogene in vitro, but its carcinogenic role in vivo remains unclear. Our study demonstrates that expression of tpr-met leads to development of mammary tumors and other malignancies in transgenic mice, and suggests that deregulated met expression may be involved in mammary carcinogenesis.
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