D M Thomas, G A Coles, D F Griffiths, J D Williams
J Clin Invest.
1994;
93(5):1881–1884
doi:10.1172/JCI117178
This article Copyright © 1994, The American Society for Clinical Investigation
Abstract
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T
he glomerular permselectivity to polydisperse neutral dextrans was compared in 6 patients with thin membrane nephropathy (TMN) and 10 healthy controls. Despite having normal renal hemodynamics and minimal proteinuria, the patients with TMN had significantly increased fractional clearance of neutral molecules with Stokes radius > 42 A. Conventional theories of glomerular barrier size selectivity cannot fully explain these data since they would predict that our patients would have had nephrotic range proteinuria.
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