A J Manheimer-Lory, A Davidson, D Watkins, N R Hannigan, B A Diamond
J Clin Invest.
1991;
87(5):1519–1525
doi:10.1172/JCI115162
This article Copyright © 1991, The American Society for Clinical Investigation
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his study describes a methodology for generating stable, cloned, EBV-transformed IgG- and IgM-producing human B cell lines. Using these lines we have characterized immunoglobulin V gene utilization in an anti-DNA-associated idiotypic system. The 31 anti-DNA-associated idiotype is encoded preferentially by the VK1 gene family, and, in all probability, reflects a germ line gene-encoded framework determinant. Analysis of these lines indicates that the DNA-binding antibodies produced by B cell lines from SLE patients may differ from DNA binding myeloma proteins and from natural autoantibodies.
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