Citations to this article


Differential solute clearances and hormone assays were used to characterize the effect of a large, protein-rich meal (1.5 g/kg) on glomerular function in 12 healthy volunteers (group I) and 12 patients with chronic glomerular disease (group II). Changes from baseline during 3 h after the meal included an elevation of plasma osmolality, progressive urinary concentration, and increasingly positive fluid balance. Plasma renin activity and arginine vasopressin levels (measured in group II only) increased significantly. Nevertheless, the rate of peak postmeal renal plasma flow became elevated by 13 and 33% in groups I and II, respectively. Corresponding peak increases in postmeal glomerular filtration rate exceeded baseline by 10 and 16%. In the proteinuric subjects of group II the fractional clearances of albumin, IgG and uncharged dextrans in the radius interval 36-54 A, declined significantly after the meal. A similar depression of the fractional dextran-clearance profile was observed also in group I. Applying the fractional clearances of relatively permeant dextrans (radii less than or equal to 44 A) to a model of hindered solute transport through an isoporous membrane, we estimate that transmembrane hydraulic pressure difference increased by 12% in group I and by between 0 to 12% in group II after protein ingestion. We conclude (i) that oral protein ingestion increases glomerular ultrafiltration pressure and rate in both normal and diseased glomeruli, (ii) that this hemodynamic response may be mediated in part by the glomerulopressor hormones angiotensin II and arginine vasopressin, and (iii) that the foregoing hemodynamic changes exert no acute adverse effect on glomerular barrier size-selectivity.


A Y Chan, M L Cheng, L C Keil, B D Myers


Total citations by year

Year: 2015 2014 2013 2011 2010 2007 2005 2004 2003 2002 2001 2000 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 Total
Citations: 1 2 1 2 3 1 1 1 1 2 1 2 2 2 1 1 4 3 2 7 7 3 2 52
Citation information

Citations to this article in year 2007 (1)

Title and authors Publication Year
Are High-Protein, Vegetable-Based Diets Safe for Kidney Function? A Review of the Literature
AM Bernstein, L Treyzon, Z Li
Journal of the American Dietetic Association 2007