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Abstract

Infrarenal heterotopic cardiac isografts maintain structural and functional integrity. We have used this transplantation model to further explore the mechanisms of thyroid hormone-induced cardiac hypertrophy. Thyroid hormone administration, 1-thyroxine (T4) 10 micrograms/animal per d, led to a significant 30% increase in total heart weight and a 40% increase in the myosin content of the in situ heart when compared with control. In contrast, T4 treatment was without effect on the heart weight, protein content, rate of protein synthesis, or calculated myosin content of the heterotopic, nonworking heart. Heterotopic hearts demonstrated a significant decrease in the percentage of the V1 myosin isoenzyme from 95% to 61%. This shift occurred in euthyroid animals but was prevented by T4 treatment. These results suggest that thyroxine-induced cardiac hypertrophy is mediated indirectly via changes in cardiac work. Myosin isoenzyme expression can be altered by changes in work load but is still responsive to increased levels of thyroid hormone.

Authors

I Klein, C Hong

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Citations to this article in year 2008 (2)

Title and authors Publication Year
Rebuilding the post-infarcted myocardium by activating ‘physiologic’ hypertrophic signaling pathways: the thyroid hormone paradigm
C Pantos, I Mourouzis, DV Cokkinos
Heart Failure Reviews 2008
Thyroid hormone and “cardiac metamorphosis”: Potential therapeutic implications
C Pantos, I Mourouzis, C Xinaris, Z Papadopoulou-Daifoti, D Cokkinos
Pharmacology & Therapeutics 2008

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