Citations to this article


Infrarenal heterotopic cardiac isografts maintain structural and functional integrity. We have used this transplantation model to further explore the mechanisms of thyroid hormone-induced cardiac hypertrophy. Thyroid hormone administration, 1-thyroxine (T4) 10 micrograms/animal per d, led to a significant 30% increase in total heart weight and a 40% increase in the myosin content of the in situ heart when compared with control. In contrast, T4 treatment was without effect on the heart weight, protein content, rate of protein synthesis, or calculated myosin content of the heterotopic, nonworking heart. Heterotopic hearts demonstrated a significant decrease in the percentage of the V1 myosin isoenzyme from 95% to 61%. This shift occurred in euthyroid animals but was prevented by T4 treatment. These results suggest that thyroxine-induced cardiac hypertrophy is mediated indirectly via changes in cardiac work. Myosin isoenzyme expression can be altered by changes in work load but is still responsive to increased levels of thyroid hormone.


I Klein, C Hong


Total citations by year

Year: 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2001 2000 1999 1998 1997 1996 1994 1992 1991 1990 1989 1987 Total
Citations: 1 1 1 3 1 2 2 2 3 1 1 1 2 3 3 4 3 3 1 2 4 4 5 3 4 60
Citation information

Citations to this article in year 2001 (3)

Title and authors Publication Year
Renin-Angiotensin System Contribution to Cardiac Hypertrophy in Experimental Hyperthyroidism: An Echocardiographic Study
A Basset, J Blanc, E Messas, A Hag├Ęge, JL Elghozi
Journal of Cardiovascular Pharmacology 2001
Negative functional effects of cGMP mediated by cGMP protein kinase are reduced in T4 cardiac myocytes
S Engel, L Yan, H Weiss, P Scholz
European Journal of Pharmacology 2001
Thyroid Hormone Increases Pacemaker Activity in Rat Neonatal Atrial Myocytes
ZQ Sun, K Ojamaa, TY Nakamura, M Artman, I Klein, WA Coetzee
Journal of Molecular and Cellular Cardiology 2001