Citations to this article


Infrarenal heterotopic cardiac isografts maintain structural and functional integrity. We have used this transplantation model to further explore the mechanisms of thyroid hormone-induced cardiac hypertrophy. Thyroid hormone administration, 1-thyroxine (T4) 10 micrograms/animal per d, led to a significant 30% increase in total heart weight and a 40% increase in the myosin content of the in situ heart when compared with control. In contrast, T4 treatment was without effect on the heart weight, protein content, rate of protein synthesis, or calculated myosin content of the heterotopic, nonworking heart. Heterotopic hearts demonstrated a significant decrease in the percentage of the V1 myosin isoenzyme from 95% to 61%. This shift occurred in euthyroid animals but was prevented by T4 treatment. These results suggest that thyroxine-induced cardiac hypertrophy is mediated indirectly via changes in cardiac work. Myosin isoenzyme expression can be altered by changes in work load but is still responsive to increased levels of thyroid hormone.


I Klein, C Hong


Total citations by year

Year: 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2001 2000 1999 1998 1997 1996 1994 1992 1991 1990 1989 1987 Total
Citations: 1 1 1 3 1 2 2 2 3 1 1 1 2 3 3 4 3 3 1 2 4 4 5 3 4 60
Citation information

Citations to this article (60)

Title and authors Publication Year
Thyroid Disease and the Heart
I Klein, S Danzi
Current Problems in Cardiology 2015
Thyroid Hormone-Regulated Cardiac microRNAs are Predicted to Suppress Pathological Hypertrophic Signaling
R Janssen, MJ Zuidwijk, DW Kuster, A Muller, WS Simonides
Frontiers in Endocrinology 2014
Myocardial Rac1 Exhibits Partial Involvement in Thyroxin-induced Cardiomyocyte Hypertrophy and Its Inhibition Is Not Sufficient to Improve Cardiac Dysfunction or Contractile Abnormalities in Mouse Papillary Muscles:
MT Elnakish, L Moldovan, M Khan, HH Hassanain, PM Janssen
Journal of Cardiovascular Pharmacology 2013
Longstanding hyperthyroidism is associated with normal or enhanced intrinsic cardiomyocyte function despite decline in global cardiac function
NY Weltman, D Wang, RA Redetzke, AM Gerdes
PloS one 2012
A Review of Literature on the Adverse Effects of Hyperthyroidism on the Heart Functional Behavior
AR Mansourian
Pakistan Journal of Biological Sciences 2012
Thyroid Hormone and the Cardiovascular System
S Danzi, I Klein
Medical Clinics of North America 2012
Cardiovascular Manifestations of Endocrine Dysfunction
RJ Deegan, WR Furman
Journal of Cardiothoracic and Vascular Anesthesia 2011
The Effect of Thyroxine-Suppressive Therapy in Patients With Euthyroid Nodular Disease
EÇ Özkaya, Y Aydin, B Özkan, SK Özkan, E Eskioğlu, S Güler
The Endocrinologist 2010
Intra-left ventricular systolic asynchrony in patients with overt hyperthyroidism
A Kırış, C Erem, G Kırış, M Koçak, Ö Gedikli, İ Nuhoğlu, M Kutlu, T Kaplan, M Gökçe, Ş Çelik
Endocrine 2010
Divergent regulation of cardiac KCND3 potassium channel expression by the thyroid hormone receptors α1 and β1: KCND3 regulation by thyroid hormone
N Gassanov, F Er, G Michels, N Zagidullin, MC Brandt, UC Hoppe
The Journal of Physiology 2009
Thyroid hormones and the cardiovascular system: Pathophysiology and interventions
G Cini, A Carpi, J Mechanick, L Cini, M Camici, F Galetta, R Giardino, MA Russo, G Iervasi
Biomedicine & Pharmacotherapy 2009
Rebuilding the post-infarcted myocardium by activating ‘physiologic’ hypertrophic signaling pathways: the thyroid hormone paradigm
C Pantos, I Mourouzis, DV Cokkinos
Heart Failure Reviews 2008
Thyroid hormone and “cardiac metamorphosis”: Potential therapeutic implications
C Pantos, I Mourouzis, C Xinaris, Z Papadopoulou-Daifoti, D Cokkinos
Pharmacology & Therapeutics 2008
Favorable clinical heart and bone effects of anti-thyroid drug therapy in endogenous subclinical hyperthyroidism
S Buscemi, S Verga, S Cottone, G Andronico, L D’Orio, V Mannino, D Panzavecchia, F Vitale, G Cerasola
Journal of Endocrinological Investigation 2007
Depressed contractile reserve and impaired calcium handling of cardiac myocytes from chronically unloaded hearts are ameliorated with the administration of physiological treatment dose of T3 in rats
Y Minatoya, K Ito, Y Kagaya, Y Asaumi, M Takeda, M Nakayama, J Takahashi, A Iguchi, K Shirato, H Shimokawa
Acta Physiologica 2007
Cardiovascular and Renal Manifestations of Hyperthyroidism
HM Syme
Veterinary Clinics of North America Small Animal Practice 2007
T4-induced cardiac hypertrophy disrupts cyclic GMP mediated responses to brain natriuretic peptide in rabbit myocardium
E Katz, Q Zhang, HR Weiss, PM Scholz
Peptides 2006
Molecular defects in cardiac myofibrillar proteins due to thyroid hormone imbalance and diabetesThis paper is a part of a series in the Journal's "Made in Canada" section. The paper has undergone peer review
J Machackova, J Barta, NS Dhalla
Canadian Journal of Physiology and Pharmacology 2005
Myocardial concentration of cardiac troponin T as an early discriminator of mechanisms of cardiac hypertrophy
MR Slaughter, S Campbell, PJ O’Brien
Comparative Clinical Pathology 2004
Does different thyroid state effect on the contractility of the cardiac muscle of eurythermal fish species, rainbow trout (Oncorhynchus mykiss, Walbaum)?
V Tiitu, M Vornanen
Journal of Thermal Biology 2003
Thyroid hormone and blood pressure regulation
S Danzi, I Klein
Current Hypertension Reports 2003
Renin-Angiotensin System Contribution to Cardiac Hypertrophy in Experimental Hyperthyroidism: An Echocardiographic Study
A Basset, J Blanc, E Messas, A Hagège, JL Elghozi
Journal of Cardiovascular Pharmacology 2001
Thyroid Hormone Increases Pacemaker Activity in Rat Neonatal Atrial Myocytes
ZQ Sun, K Ojamaa, TY Nakamura, M Artman, I Klein, WA Coetzee
Journal of Molecular and Cellular Cardiology 2001
Negative functional effects of cGMP mediated by cGMP protein kinase are reduced in T4 cardiac myocytes
S Engel, L Yan, H Weiss, P Scholz
European Journal of Pharmacology 2001
Thyroid Hormone Stimulates Na, K-ATPase Gene Expression in the Hemodynamically Unloaded Heterotopically Transplanted Rat Heart
Y Shao, K Ojamaa, I Klein, F Ismail-Beigi
Thyroid 2000