L M Slater, P Sweet, M Stupecky, S Gupta
J Clin Invest.
1986;
77(4):1405–1408
doi:10.1172/JCI112450
This article Copyright © 1986, The American Society for Clinical Investigation
Abstract
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T
he development of drug resistance by tumor cells is a major obstacle to the cure of human malignancy. Cyclosporin A (CsA) completely reverses primary resistance to vincristine and cross resistance to daunorubicin in a pleiotropic drug-resistant subline of human T cell acute lymphatic leukemia. This subline is over 50-fold resistant to vincristine and fivefold resistant to daunorubicin. CsA has little effect on vincristine or daunorubicin activity in drug-sensitive parental leukemia and corrects daunorubicin resistance without altering cellular daunorubicin accumulation.
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