Published in Volume
77, Issue 4 (April 1986)
J Clin Invest. 1986;77(4):1399–1401.
doi:10.1172/JCI112448.
Copyright ©
1986, The American Society for
Clinical Investigation.
Research Article
Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.
A A Rossini, J P Mordes, D L Greiner, K Nakano, M C Appel and E S Handler
Published April 1986
We report that transfusions of RT1u Wistar-Furth (WF) spleen cells prevented spontaneous diabetes in the RT1u BB/W rat while RT1b Buffalo rat spleen cells did not. In addition, donor origin WF T lymphocytes were detected in nondiabetic-susceptible BB/W recipients 5 mo after transfusion. Survival of donor-origin lymphocytes may provide the cellular mechanism by which major histocompatibility complex-compatible WF spleen cell transfusions prevent BB rat diabetes.
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