JCI - Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors

Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors

Jun-Ichi Kaide, Fan Zhang, Yuan Wei, Houli Jiang, Changhua Yu, WenHui Wang, Michael Balazy, Nader G. Abraham, Alberto Nasjletti

Published in Volume 107, Issue 9

J Clin Invest. 2001; 107(9):1163–1171 doi:10.1172/JCI11218

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Figure 8

Concentration-response curves to phenylephrine in freshly dissected rat renal interlobar artery rings bathed in media with (EC₅₀, 0.06 ± 0.01^A μmol/l; R_max, 3.86 ± 0.18 mN/mm; n = 7) and without iberiotoxin (IBTX, 10 nmol/l; EC₅₀, 0.38 ± 0.03 μmol/l; R_max, 3.96 ± 0.11 mN/mm; n = 15), TEA (1 mmol/l; EC₅₀, 0.10 ± 0.01^A μmol/l; R_max, 3.87 ± 0.19 mN/mm; n = 8), or TEA plus CrMP (30 μmol/l; EC₅₀, 0.09 ± 0.01^A μmol/l; R_max, 3.83 ± 0.22 mN/mm; n = 8). L-NAME (1 mmol/l) was included in the buffer used in contractility studies. Results are mean ± SEM. ^AP < 0.05 relative to control.