Advertisement

Citations to this article

Abstract

Hypertension and glucose intolerance, determined in a random population sample (n = 2,475), showed a highly significant (P less than 0.001) association from the mildest levels of both conditions, independent of the confounding effects of age, sex, obesity, and antihypertensive medications. Summary rate ratios for hypertension were 1.48 (1.18-1.87) in abnormal tolerance and 2.26 (1.69-2.84) in diabetes compared with normal tolerance. Altogether, 83.4% of the hypertensives were either glucose-intolerant or obese--both established insulin-resistant conditions. Fasting and post-load insulin levels in a representative subgroup (n = 1,241) were significantly elevated in hypertension independent of obesity, glucose intolerance, age, and antihypertensive medications. The mean increment in summed 1- and 2-h insulin levels (milliunits per liter) compared with nonobese normotensives with normal tolerance was 12 for hypertension alone, 47 for obesity alone, 52 for abnormal tolerance alone, and 124 when all three conditions were present. The prevalence of concentrations (milliequivalents per liter) of erythrocyte Na+ greater than or equal to 7.0, K+ less than 92.5, and plasma K+ greater than or equal to 4.5 in a subsample of 59 individuals with all combinations of abnormal tolerance obesity and hypertension was compared with those in 30 individuals free of these conditions. Altogether, 88.1% of the former vs. 40.0% of the latter group presented at least one of these three markers of internal cation imbalance (P less than 0.001). We conclude that insulin resistance and/or hyperinsulinemia (a) are present in the majority of hypertensives, (b) constitute a common pathophysiologic feature of obesity, glucose intolerance, and hypertension, possibly explaining their ubiquitous association, and (c) may be linked to the increased peripheral vascular resistance of hypertension, which is putatively related to elevated intracellular sodium concentration.

Authors

M Modan, H Halkin, S Almog, A Lusky, A Eshkol, M Shefi, A Shitrit, Z Fuchs

×

Total citations by year in Crossref

Year: 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 Total
Citations: 8 8 11 9 7 8 13 19 14 14 13 17 12 20 28 29 43 25 24 26 37 45 30 38 23 17 23 12 5 578
Citation information

Citations to this article in Crossref (578)

Title and authors Publication Year
Coordinate control of adipose ‘browning’ and energy expenditure by β-adrenergic and natriuretic peptide signalling
S Collins, R Sarzani, M Bordicchia
International Journal of Obesity Supplements 2014
Evaluation of the Associations between Vascular Endothelial Function and Coronary Artery Stenosis in Patients with Elevated Blood Pressure during Coronary Angiography
R Yang, J Yu
The Heart Surgery Forum 2014
Hyperinsulinemic syndrome: The metabolic syndrome is broader than you think
CT Kelly, J Mansoor, GL Dohm, WH Chapman, JR Pender, WJ Pories
Surgery 2014
Cardiomyocyte changes in the metabolic syndrome and implications for endogeneous protective strategies
W Oosterlinck, P Herijgers
Expert Review of Cardiovascular Therapy 2014
The relationship between insulin-sensitive obesity and cardiovascular diseases in a Chinese population
J Lu, Y Bi, T Wang, W Wang, Y Mu, J Zhao, C Liu, L Chen, L Shi, Q Li, Q Wan, S Wu, G Qin, T Yang, L Yan, Y Liu, G Wang, Z Luo, X Tang, G Chen, Y Huo, Z Gao, Q Su, Z Ye, Y Wang, H Deng, X Yu, F Shen, L Chen, L Zhao, M Dai, M Xu, Y Xu, Y Chen, S Lai, G Ning
International Journal of Cardiology 2014
Blunted GABA-mediated inhibition within the dorsomedial hypothalamus potentiates the cardiovascular response to emotional stress in rats fed a high-fat diet
AR Abreu, AR Abreu, LT Santos, AA Souza, LG Silva, DA Chianca, RC Menezes
Neuroscience 2014
Effect of antihypertensive treatments on insulin signalling in lympho-monocytes of essential hypertensive patients: A pilot study
CD Ciuceis, V Flati, C Rossini, A Rufo, E Porteri, JD Gregorio, B Petroboni, EL Boria, C Donini, E Pasini, EA Rosei, D Rizzoni
Blood Pressure 2014
Sympathetic Activity and Markers of Cardiovascular Risk in Nondiabetic Severely Obese Patients: The Effect of the Initial 10% Weight Loss
EA Lambert, T Rice, N Eikelis, NE Straznicky, GW Lambert, GA Head, C Hensman, MP Schlaich, JB Dixon
American Journal of Hypertension 2014
Nutritional Management of Renal Disease
A Molfino, BR Don, GA Kaysen
Nutritional Management of Renal Disease 2013
Progression of cardiovascular and endocrine dysfunction in a rabbit model of obesity
GA Eppel, JA Armitage, N Eikelis, GA Head, RG Evans
Hypertension Research 2013
Hypertension in obesity: is leptin the culprit?
SE Simonds, MA Cowley
Trends in Neurosciences 2013
Effect of orally administered L. fermentum NCIMB 5221 on markers of metabolic syndrome: an in vivo analysis using ZDF rats
C Tomaro-Duchesneau, S Saha, M Malhotra, ML Jones, A Labbé, L Rodes, I Kahouli, S Prakash
Applied Microbiology and Biotechnology 2013
Impaired fasting glucose as an independent risk factor for hypertension among healthy middle-aged Japanese subjects with optimal blood pressure: the Yuport Medical Checkup Centre retrospective cohort study
M Morio, M Inoue, K Inoue, K Akimoto
Diabetology & metabolic syndrome 2013
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
C Hales, D Barker
International Journal of Epidemiology 2013
Risk of postprandial insulin resistance: The liver/vagus rapport
MP Macedo, IS Lima, JM Gaspar, RA Afonso, RS Patarrão, YB Kim, RT Ribeiro
Reviews in Endocrine and Metabolic Disorders 2013
Anti-obesity and hypolipidaemic effects of Nelumbo nucifera seed ethanol extract in human pre-adipocytes and rats fed a high-fat diet: Anti-obesity and hypolipidaemic effects of Nelumbo nucifera seed ethanol extract
JS You, YJ Lee, KS Kim, SH Kim, KJ Chang
Journal of the Science of Food and Agriculture 2013
Obesity-related hypertension: Pathogenesis, cardiovascular risk, and treatment-A position paper of the The Obesity Society and the American Society of Hypertension
L Landsberg, LJ Aronne, LJ Beilin, V Burke, LI Igel, D Lloyd-Jones, J Sowers
Obesity 2012
Effects of candesartan in hypertensive patients with type 2 diabetes mellitus on inflammatory parameters and their relationship to pulse pressure
M Sakamoto, H Suzuki, T Hayashi, H Iuchi, T Isaka, N Sakamoto, Y Kayama, K Tojo, M Yoshimura, K Utsunomiya
Cardiovascular Diabetology 2012
Basal state hyperinsulinemia in healthy normoglycemic adults heralds dysglycemia after more than two decades of follow up: Hyperinsulinemia Heralds Dysglycemia
R Dankner, A Chetrit, MH Shanik, I Raz, J Roth
Diabetes/Metabolism Research and Reviews 2012
16,17-Dihydro-17b-hydroxy isomitraphylline alkaloid as an inhibitor of DPP-IV, and its effect on incretin hormone and β-cell proliferation in diabetic rat
A Shukla, BP Srinivasan
European Journal of Pharmaceutical Sciences 2012
Physical Activity and Cardiovascular Risk Factors in Spanish Children Aged 11-13 Years
A Cordova, G Villa, A Sureda, JA Rodriguez-Marroyo, MP Sánchez-Collado
Revista Española de Cardiología (English Edition) 2012
Effect of Pioglitazone on Arterial Baroreflex Sensitivity and Sympathetic Nerve Activity in Patients with Acute Myocardial Infarction and Type 2 Diabetes Mellitus:
H Yokoe, F Yuasa, R Yuyama, K Murakawa, Y Miyasaka, S Yoshida, S Tsujimoto, T Sugiura, T Iwasaka
Journal of Cardiovascular Pharmacology 2012
Brainstem sensing of meal-related signals in energy homeostasis
AA Young
Neuropharmacology 2012
Actividad física y factores de riesgo cardiovascular de niños españoles de 11-13 años
A Cordova, G Villa, A Sureda, JA Rodriguez-Marroyo, MP Sánchez-Collado
Revista Española de Cardiología 2012
Obesity: Prevention and Treatment
P Grandjean
Obesity: Prevention and Treatment 2012

Advertisement
Advertisement