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B S Nepom, G T Nepom, E Mickelson, J G Schaller, P Antonelli, J A Hansen
J Clin Invest. 1984;
74(1):287
doi:10.1172/JCI111413
Abstract |
Full text
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T
he structural and functional heterogeneity of HLA-DR4-associated specificities was investigated in patients with seropositive juvenile rheumatoid arthritis, a DR4-associated disease. Using a combination of HLA-D analysis by mixed lymphocyte culture and electrophoretic analysis of immunoprecipitated Ia molecules by two-dimensional polyacrylamide gels, we observed a surprisingly homogeneous pattern of HLA-D antigen expression. All patients expressed common structural products of the DR and DS loci, and 7/12 homozygous DR4 patients expressed a rare and subtle HLA-D heterozygous phenotype.
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(34)
| Title and authors |
Publication |
Year |
Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope
Sampath Prahalad, Susan D. Thompson, Karen N. Conneely, Yunxuan Jiang, Traci Leong, Jennifer Prozonic, Milton R. Brown, Lori A. Ponder, Sheila T. Angeles-Han, Larry B. Vogler
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Arthritis Rheum
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2012 |
POLYARTHRITIS
Alan M. Rosenberg, Kiem G. Oen
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Textbook of Pediatric Rheumatology
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2011 |
Teasing apart the complex genetics of human autoimmunity: lessons from rheumatoid arthritis
Peter K Gregersen
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Clinical Immunology
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2003 |
Genetics of rheumatoid arthritis: is there a scientific explanation for the human leukocyte antigen association?
Jane H. Buckner, Gerald T. Nepom
|
Current Opinion in Rheumatology
|
2002 |
HLA and Rheumatoid Arthritis
Gerald T. Nepom
|
|
2000 |
Methotrexate therapy for juvenile rheumatoid arthritis in Japan — surveillance with a questionnaire at seven main facilities
Yukoh Aihara, Tomoyuki Imagawa, Shigeki Katakura, Shuichi Ito, Takako Miyamae, Masaaki Ibe, Toshihiro Mitsuda, Shumpei Yokota
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Japanese Journal of Rheumatology
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1999 |
HLA haplotype sharing in rheumatoid arthritis sibships: Risk estimates subdivided by proband genotype
Alan S. Rigby, Alex J. MacGregor, Glenys Thomson
|
Genet. Epidemiol.
|
1998 |
Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions
Gerald T. Nepom, Dawei Ou, Terry P. Lybrand, Carol Deweese, Mary Ellen Domeier, Jane H. Buckner, Leslie A. Mitchell, Aubrey J. Tingle
|
Eur. J. Immunol.
|
1996 |
HLA Class II Genotypes Associated With Early-Onset Periodontitis: DQB1 Molecule Primarily Confers Susceptibility to the Disease
Hideki Ohyama, Shogo Takashiba, Kosuke Oyaizu, Atsushi Nagai, Taeko Naruse, Hidetoshi Inoko, Hidemi Kurihara, Yoji Murayama
|
Journal of Periodontology
|
1996 |
The genotypic distribution of shared-epitope DRB1 alleles suggests a recessive mode of inheritance of the rheumatoid arthritis disease-susceptibility gene
Toni I. Evans, Jinfeng Han, Rovinder Singh, George Moxley
|
Arthritis Rheum
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1995 |
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