Advertisement

Citations to this article

Abstract

To see whether circulating granulocytes are necessary for the lung vascular reaction to endotoxin, we measured the endotoxin response in chronically instrumented sheep before and after granulocyte depletion with hydroxyurea. Granulocyte depletion did not affect the pulmonary hypertension caused by endotoxin (peak mean pulmonary artery pressures = 38 +/- 2 cm H2O before depletion and 42 +/- 2 after depletion, P = NS). The late phase increase in lung lymph flow after endotoxin was significantly lower in the granulocytopenic animals as reflected by lung lymph flow (mean steady state lymph flow before depletion = 30.6 +/- 2.0 SE ml/h; mean steady state lymph flow after granulocyte depletion = 15.4 +/- 1.0; P less than 0.01) even though late phase pulmonary vascular pressures were similar before and after granulocyte depletion. Lung lymph protein clearance (lymph flow x lymph/plasma protein concentration) was also significantly lower after granulocyte depletion (mean steady state before depletion = 2.14 +/- 1.4 SE ml/h; and after depletion = 10.4 +/- 1.0; P less than 0.01). We conclude that circulating granulocytes are necessary for the development of increased lung vascular permeability to fluid and protein following endotoxin. The pulmonary vasopressor effects of endotoxin in sheep are independent of granulocytes.

Authors

A C Heflin Jr, K L Brigham

×

Total citations by year

Year: 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 Total
Citations: 4 2 5 1 4 9 2 4 3 3 6 4 2 7 2 5 6 4 5 10 12 10 11 8 23 13 18 9 16 4 4 216
Citation information

Citations to this article in year 2002 (6)

Title and authors Publication Year
Inosine Exerts a Broad Range of Antiinflammatory Effects in a Murine Model of Acute Lung Injury
L Liaudet, JG Mabley, P Pacher, L Virág, FG Soriano, A Marton, G Haskó, EA Deitch, C Szabó
Annals of Surgery 2002
The pulmonary physician in critical care * 6: The pathogenesis of ALI/ARDS
GJ Bellingan
Thorax 2002
Inosine exerts a broad range of antiinflammatory effects in a murine model of acute lung injury
L Liaudet, JG Mabley, P Pacher, L Virág, FG Soriano, A Marton, G Haskó, EA Deitch, C Szabó
Annals of Surgery 2002
ARDS and the multiple organ dysfunction syndrome
RG Khadaroo, JC Marshall
Critical Care Clinics 2002
Inosine Exerts a Broad Range of Antiinflammatory Effects in a Murine Model of Acute Lung Injury:
L Liaudet, JG Mabley, P Pacher, L Virág, FG Soriano, A Marton, G Haskó, EA Deitch, C Szabó
Annals of Surgery 2002
Activation of Poly(ADP-Ribose) Polymerase-1 Is a Central Mechanism of Lipopolysaccharide-Induced Acute Lung Inflammation
L Liaudet, P Pacher, JG Mabley, L Virág, FG Soriano, G Haskó, C Szabó
American journal of respiratory and critical care medicine 2002

Advertisement
Advertisement