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Citations to this article

Abstract

Other investigators have demonstrated that concentrations of immunoreactive somatostatin (IRS) are higher in blood from the hepatic portal vein or its tributaries than in blood from the hepatic or peripheral systemic veins of man and animals. This suggests that there is hepatic extraction of IRS from the portal system in vivo. In the rat, portal vein plasma IRS is reported to be heterogeneous and to contain, in part, a 1,600 mol wt form of IRS which is immunochemically similar to synthetic somatostatin and not significantly bound to high molecular weight plasma protein. Our study was undertaken to determine directly whether unbound synthetic cyclic somatostatin was cleared by the rat liver perfused through the hepatic portal vein in vitro with a recirculating, plasma-free, erythrocyte-containing perfusate.

Authors

Harold Sacks, L. Cass Terry

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Year: 2011 1995 1987 1986 1984 1983 1981 Total
Citations: 1 1 1 1 3 4 2 13
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Citations to this article (13)

Title and authors Publication Year
Comprehensive Physiology
AS Rebuck, AS Slutsky
Comprehensive Physiology 2011
Brain somatostatin receptors in a rat model of acute liver failure
MD Boyano-Ad´┐Żnez, V Barrios, E Afulla
Synapse 1995
Hepatic clearance of somatostatin and gastrin-releasing peptide
MM Wolfe, JW Doyle, JE McGuigan
Life Sciences 1987
Endogenous somatostatin and the gut
MR Lucey
Gut 1986
INFUSION OF GRADED CONCENTRATIONS OF SOMATOSTATIN IN MAN: PHARMACOKINETICS AND DIFFERENTIAL INHIBITORY EFFECTS ON PITUITARY AND ISLET HORMONES
A Skamene, YC Patel
Clinical Endocrinology 1984
Contribution of the pancreas to circulating somatostatin-like immunoreactivity in the normal dog
GJ Taborsky, JW Ensinck
Journal of Clinical Investigation 1984
Characterization and measurement of plasma somatostatin-like immunoreactivity in a sahelian lizard (Varanus exanthematicus) during starvation
M Dupe-Godet
Comparative Biochemistry and Physiology Part A: Physiology 1984
Somatostatin reduces gastric mucosal blood flow in normal subjects but not in patients with cirrhosis of the liver
A Sonnenberg, C West
Gut 1983
Splanchnic and Hepatic Metabolism of Somatostatin: A Study in Cirrhotic Patients with a Portacaval Shunt
S Webb, D Kravetz, J Bosch, JA Wass, J Evans, R Gomis, LH Rees, J Rodes
Hepatology 1983
Enzymic inactivation of hypothalamic regulatory hormones
EC Griffiths, JR McDermott
Molecular and Cellular Endocrinology 1983
Alterations in somatostatin and other islet cell functions in the spontaneously diabetic BB Wistar rat: Biochemical and morphological characterization
YC Patel, D Ruggere, F Malaisse-Lagae, L Orci
Metabolism 1983
Metabolism of somatostatin and its analogues by the liver
JM Conlon, J Whittaker, V Hammond, KG Alberti
Biochimica et Biophysica Acta (BBA) - General Subjects 1981
Hepatic and renal metabolism of somatostatin-like immunoreactivity. Simultaneous assessment in the dog
KS Polonsky, JB Jaspan, M Berelowitz, DS Emmanouel, J Dhorajiwala
Journal of Clinical Investigation 1981

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