Published in Volume
60, Issue 6
(December 1977)J Clin Invest.
1977, The American Society for
Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis.
Published December 1977
Pi phenotypes of alpha-1-protease inhibitor were determined by isoelectric focusing and print immunofixation in 96 English children suffering from juvenile chronic polyarthritis. A significantly increased frequency of the MZ phenotype (10.41%) was found in comparison with a geographically matched control population (1.6%). The results of this study suggest that the possession of a Z-deficient allele of alpha-1-protease inhibitor could be a predisposing, aggravating, or perpetuating factor in the articular damage occurring in juvenile chronic polyarthritis.
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