J L Carpentier, F Malaisse-Lagae, W A Müller
J Clin Invest.
1977;
60(5):1174–1182
doi:10.1172/JCI108870
This article Copyright © 1977, The American Society for Clinical Investigation
Abstract
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T
he release of glucagon induced in isolated rat islets by arginine or by calcium deprivation has been subjected to combined functional and morphological quantifications. Arginine-stimulated glucagon release was associated with a significant increase of morphological events linked to exocytosis. By contrast, the paradoxical events linked to exocytosis. By contrast, the paradoxical release of glucagon provoked by calcium deprivation, although accompanied by a significant loss of granule stores, was not associated with an increase of morphologically detectable exocytosis.
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