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Abstract

This study was designed to examine whether prostaglandin E2 can directly affect sodium transport across isolated perfused rabbit renal collecting tubules. Changes in transepithelial potential and isotopic sodium fluxes in response to peritubular prostaglandin E2 were measured. In addition, changes in transepithelial potential of the outer medullary collecting tubule in response to prostaglandin E2 were also measured. With few exceptions, all rabbits received 5 mg/day desoxycorticosterone acetate for 4-11 days before experimentation. The results of the experiments show that: (a) prostaglandin E2 inhibits the negative transepithelial potential in the cortical collecting tubule as well as the outer medullary collecting tubule; (b) prostaglandin E2 inhibits net sodium transport out of the lumen by inhibiting efflux while backflux is unaffected; (c) prostaglandin E2 produces this inhibition within 15 min, and the effects are dose dependent and reversible. These results suggest that prostaglandin E2 may modulate sodium transport in vivo and may contribute to the final regulation of sodium excretion.

Authors

J B Stokes, J P Kokko

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Citations to this article in year 2005 (2)

Title and authors Publication Year
Comparative Effects of Indomethacin and Nabumetone on Urine and Electrolyte Output in Conscious Rats
I Long, HJ Singh, GJ Rao
Journal of Pharmacological Sciences 2005
CELL SURVIVAL IN THE HOSTILE ENVIRONMENT OF THE RENAL MEDULLA
W Neuhofer, FX Beck
Annual Review of Physiology 2005

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