Citations to this article


This study was designed to examine whether prostaglandin E2 can directly affect sodium transport across isolated perfused rabbit renal collecting tubules. Changes in transepithelial potential and isotopic sodium fluxes in response to peritubular prostaglandin E2 were measured. In addition, changes in transepithelial potential of the outer medullary collecting tubule in response to prostaglandin E2 were also measured. With few exceptions, all rabbits received 5 mg/day desoxycorticosterone acetate for 4-11 days before experimentation. The results of the experiments show that: (a) prostaglandin E2 inhibits the negative transepithelial potential in the cortical collecting tubule as well as the outer medullary collecting tubule; (b) prostaglandin E2 inhibits net sodium transport out of the lumen by inhibiting efflux while backflux is unaffected; (c) prostaglandin E2 produces this inhibition within 15 min, and the effects are dose dependent and reversible. These results suggest that prostaglandin E2 may modulate sodium transport in vivo and may contribute to the final regulation of sodium excretion.


J B Stokes, J P Kokko


Total citations by year in Crossref

Year: 2015 2014 2012 2011 2010 2009 2007 2005 2004 2003 2002 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 Total
Citations: 1 1 2 2 1 1 1 2 1 2 1 4 1 2 1 1 5 5 3 9 7 3 5 6 11 7 7 6 15 15 6 3 3 140
Citation information

Citations to this article in Crossref (140)

Title and authors Publication Year
Atrial Natriuretic Factor: Implications for Cardiac Pacing and Electrophysiology
HF Clemo, CM Baumgarten, BS Stambler, MA Wood, KA Ellenbogen
Pacing and Clinical Electrophysiology 1994
Nephrocalcinosis in pseudohypoaldosteronism and the effect of indomethacin therapy
H Shalev, M Ohali, O Abramson, M Phillip
The Journal of Pediatrics 1994
Clinical manifestations and management of acute lithium intoxication
MD Okusa, LJ Crystal
The American Journal of Medicine 1994
Cellular signalling of PGE2 and its selective receptor analogue sulprostone in rabbit cortical collecting duct
RL Hébert
Prostaglandins, Leukotrienes and Essential Fatty Acids 1994
In situ hybridization and localization of mRNA for the rabbit prostaglandin EP3 receptor
MD Breyer, HR Jacobson, LS Davis, RM Breyer
Kidney International 1993
Prostaglandin synthesis inhibition stimulates lithium reabsorption in Henle's loop in rats
WH Boer, R Fransen, P Boer, R Roos, HA Koomans
Kidney International 1993
Renal responses to magnesium lithospermate B in rats with adenine-induced renal failure
T Yokozawa, TW Lee, H Oura, M Hattori, GI Nonaka, I Nishioka
Phytotherapy Research 1993
Amplification of the Arachidonic Acid Cascade: Implications for Pharmacologic Intervention
NR Baird, AR Morrison
American Journal of Kidney Diseases 1993
Interactions between glucocorticoids and mineralocorticoids in the regulation of renal electrolyte transport
AS Brem, DJ Morris
Molecular and Cellular Endocrinology 1993
Mechanisms regulating renal sodium excretion during development
JE Robillard, FG Smith, JL Segar, EN Guillery, PA Jose
Pediatric Nephrology 1992
Modulation of Ion Transport in Cultured Rabbit Tracheal Epithelium by Lipoxygenase Metabolites
ME Egan, MH Wagner, PL Zeitlin, WB Guggino
American journal of respiratory cell and molecular biology 1992
Haemodynamic effects of magnesium lithospermate B in rats with renal failure
T Yokozawa, TW Lee, H Oura, XY Zhang, M Hattori, GI Nonaka, I Nishioka
Phytotherapy Research 1992
Effects of acetylsalicylic acid on renal function in patients with chronic heart failure
GA Riegger, HW Kahles, D Elsner, EP Kromer, K Kochsiek
The American Journal of Medicine 1991
Characterization of partially purified prostaglandin E2 receptor from the canine renal medulla: evidence for physical association of the receptor protein with the inhibitory guanine nucleotide-binding protein
T Watanabe, T Shimizu, A Nakao, S Taniguchi, Y Arata, T Teramoto, Y Seyama, M Ui, K Kurokawa
Biochimica et Biophysica Acta (BBA) - General Subjects 1991
Physiological changes of aging affecting salt and water balance
M Miller, GC Gold, DA Friedlander
Reviews in Clinical Gerontology 1991
Inhibitory effects of beta adrenoceptor antagonist, atenolol, on the thromboxane system in the kidney of spontaneously hypertensive rats
N Hirawa, Y Uehara, A Numabe, T Ikeda, S Yagr, T Sugimoto, M Ishii
Prostaglandins, Leukotrienes and Essential Fatty Acids 1991
Different mechanisms of polyuria and natriuresis associated with paroxysmal supraventricular tachycardia
T Fujii, S Kojima, M Imanishi, T Ohe, T Omae
The American Journal of Cardiology 1991
Nonsteroidal Anti-Inflammatory Drugs: Effects on Kidney Function
A Whelton, CW Hamilton
The Journal of Clinical Pharmacology 1991
Renal tubular arachidonic acid metabolism
JV Bonventre, R Nemenoff
Kidney International 1991
Pharmacology of Furosemide in the Horse: A Review
KW Hinchcliff, WW Muir
Journal of Veterinary Internal Medicine 1991
Effects of acetylsalicylic acid on renal function in patients with chronic heart failure
GA Riegger, HW Kahles, D Elsner, EP Kromer, K Kochsiek
The American Journal of Medicine 1991
Renal Responses to Magnesium Lithospermate B
T Yokozawa, TW Lee, HY Chung, H Oura, GI Nonaka, I Nishioka
Journal of Pharmacy and Pharmacology 1990
Renal sodium handling and stimulation of medullary NaKATPase during blockade of prostaglandin synthesis
D Rubinger, H Wald, P Scherzer, MM Popovtzer
Prostaglandins 1990
Factors governing sodium and chloride transport across the inner medullary collecting duct
AS Rocha, LH Kudo
Kidney International 1990
Prostaglandin E 2 binding sites in human renal tissue: characterization and localization by radioligand binding and autoradiography
LO Eriksson, B Larsson, H Hedlund, KE Andersson
Acta Physiologica Scandinavica 1990